Kathleen Clifford made her screen debut in the 1917 William Bertram directed mystery serial Who Is Number One? opposite silent film actor Cullen Landis. She would appear in several high profile roles throughout the late 1910s and early 1920s. Most notably: opposite Douglas Fairbanks, Sr. in the 1919 comedy When the Clouds Roll By , in the Ouida Bergère penned and George Fitzmaurice directed crime drama Kick In opposite Betty Compson, May McAvoy and Bert Lytell (1922), and in the role of 'Queen Berengaria' opposite Wallace Beery and the young actress Marguerite De La Motte in Richard the Lion-Hearted (1923). Clifford's last silent film would be in the 1928 James Cruze directed comedy Excess Baggage opposite the popular silent film actor William Haines.