Louise Fazenda was born in Lafayette, Indiana. Her father, Joseph Fazenda, was a merchandise broker. After moving west Louise attended Los Angeles High School and St. Mary's Convent. Before trying motion pictures, she worked for a dentist, a candy store owner, and a tax collector.
Fazenda got her start in comedy shorts as early as 1913 with Joker Studios, frequently appearing with Max Asher and Bobby Vernon. She was soon recruited for Mack Sennett's troupe at Keystone Studios.
As with many Keystone actors, Fazenda's star soon grew larger than Sennett was willing to pay for, and she left Sennett in the early 1920s for better roles and more money. She took a break from making motion pictures in 1921-